I have heard anecdotal reports from a friend whose mother had a very good response to Anatabloc for early Alzheimer's. She said they were very encouraged for the first 2 months. Things have leveled off since but they still include it as part of her regiment. I didn't ask about the CRP. She does complain about the number of tablets every day but they do not want to change anything at this point.

Plus, it is "Johns Hopkins" ... no apostrophe between the "n" and "s."

Donna,

This is a very serious discussion we are having here. And it is important to me. I am very concerned about the truth. Please answer this question truthfully. And before you do please call your Dad and ask him the answer. Tell him John McKeon asked you. Tell him you are going to respond to a question on the web site raising money that his name is attached to. Tell him John McKeon feels very strongly about telling the truth. Is your father continuing to take Antatblock/RCP006 daily and to this day. Your Dad knows how you can contact me if you feel the need to. Please tell this website the truthful answer to this question.

As long as we are acting like vermin and randomly criticizing the spelling of people who are going through incredibly difficult circumstances, the word you want is "whose" and not "who's." In the English language, "who's" is a conjunction that stands in for the words "who is." The best thing about my life is that I don't know you.

Ms. Suro--please accept my apologies on behalf of the human race.

-Not John McKeon

Get a life!

Also, John, it is customary to end questions with question marks. Who in the world would write "Who wrote this."? I mean, it sounds like a question but then it ends with a period. Certainly noted grammarian John McKeon, who has literally nothing better to do than criticize internet spelling, would never make such a silly mistake. So who are you really?

Free John McKeon!

-Not John McKeon

Donna,first let me express how appalled I am at some of the comments posted in the replies to your postings.I was unaware of the anatabloc issue when I asked for your father's treatment protocol.it seems that there are many people who have a vested interest in having Star Scientific fail.Many posters have no qualms in saying very unpleasant things in an attempt to gain an edge in their favor.I am sorry that you have been subject to such outrageous posting.please know that there are many of us who wish you sand your family well and are

Her dad said in a public sec filing that he is enthusiastic about Anatabloc, we now know he has Alz and was taking it for alz, he said in the sec filing he was going to buy shares, he then went and publicly bought shares. She is telling people she likes the idea of taking coconut oil, b-12, and dieting, and not anatabloc. John Mckeon is telling her to call her dad and demands that she admit he is still taking Anatabloc for alz. He sounds like he knows more than her. People need to realize that R. Sharp is an old pro. He wouldn't tell his daughter or anyone else insider info he was privy to at Star Scientific. She probably doesnt know 1/100'th of what her dad knows about Anatabloc.

Donna, the company that makes Anatabloc recommends that peopled take 3-6 of the lozenges per day but I've heard of people with serious diseases taking the equivalent of 10-20 per day to really try to fight it. Was your dad taking well over the recommended 3-6 by any chance, which may have been the reason for the problems you spoke of? You mentioned him taking higher doses and eating Cigrx all day so I thought I would ask. Thank you

To all whom it may concern:

I may have some longer and more general comments at a later time, and I state that I will post them and this with utmost respect and regard to all concerned. I am concerned for the good of the persons involved, for the accurate representation of what is taking place, and for the best possible outcome for all concerned.

Specifically, for now (to a single point of information/discussion), I note Ms. Suro's statement above that,

"We called them his "tic-tacs" because he had them in his pocket and would pop them in his mouth throughout the day like you would a pack of tic-tacs. He really liked the taste of them and I think the action of taking the tablets throughout the day was comforting to him. I think your comment that his side effects could have been caused by the higher dose is absolutely possible."

With great respect and concern, I urge the following consideration.

In light of the very nature of the illness in question, Alzheimer's, does it seem wise at any point after definite diagnosis and signs of deterioration of memory (pretty much required for diagnosis) for the patient in question to dose himself with something of which he or she can afford unlimited quantities, something that is sold "OTC" without restriction, something that actually tastes good to take, and something which, one presumes, no one (else) is monitoring in terms of amounts consumed?

I know that the person in question, God bless him, is used to autonomy in every respect, but it appears by this very discussion that there is a crucial problem afoot here (now discovered), not just concerning the taking of Anatabloc but with any regimen not being directly overseen and monitored (in amount used, via prescription control). It cannot be emphasized enough that there is no good to be had by the use of anything with pharmaceutical effect without control or notice of amount taken. Nothing, not even water, can be safely consumed without limitation.

It does indeed seem highly likely that over consumption is a reasonable explanation for the reported problem(s) encountered, considering Ms. Suro's comments above. It takes no more than 10 minutes to dissolve an Anatabloc in the mouth. Mr. Sharp could easily have been consuming 30, 40, 60 or more of these a day if no one was counting.

It is probably a comment on the safety of this compound that the person in question felt and has experienced no greater problem than reported in this blog.

I personally have suffered rather severe consequences due to zinc poisoning due to its presence as "supplement" in many more of my dietary components than I was aware.

Because the use of supplements as a "mainstay" of treatment is being discussed here (and I may introduce another possibility for that at a later time), I urge whoever is and should be concerned about this person's care to see to it that any and all "supplementation" be monitored as to frequency and amount by some one or ones other than the patient ... who may be unaware, completely, how much of an easily obtained, good tasting supplement he or she is taking.

I have read several reports of others trying Anatabloc, and its predecessor supplement, in treating loved ones with AD (mostly through "the association"), and they all have reported monitoring the amount consumed, some remarking how eagerly the patient will take them due to the nice taste.

I must opine that, as you go forward, you (and all) consider these crucial aspects of trying any and every avenue of possible aid.

(1) Too much of any dietary and/or pharmaceutical component in the patient's "intake" can be as bad as, and in many cases disastrously worse than, too little of it. Plus,

(2) of all illness-plagued "patients", those with AD would seem certain to be at the top of the list of persons who need to be closely monitored as to diet, supplementation, and medication, due to the very nature of the problem.

I am helping take care of my own father, who has non-AD dementia at 90. He sometimes resents, not too seriously, the lack of autonomy about these things (diet for diabetes/obesity and 13 medications, plus supplementation), but we go over daily the "education/re-education" routine of why it is necessary, and that keeps things in perspective for him.

I am sure that those who are in the picture here will do the same for the good of, the health of, the AD patient in question. This discussion reveals that it is not too early, but rather likely a little late, to start ... but now is so much better than later.

Donna, thanks for taking the time to answer these responses and questions. I wish your family the best. Your dad is a legend. My question is.....does your Dad's doctors think that Anatabloc interacted with your Dad's thyroid, which could explain the fast metabolism and cold spells? The company behind Star is doing lots of Thyroid tests with Anatabloc and are now referring to Anatabloc as a metabolism product so I thought I would ask. Could Anatabloc be throwing the thyroid into disarray?

First off where is this product acually manufactured? Second, if it doesn't work for everyone why would tests show positive results in all blood work? Sure seems like a scam to me. Show me a blood test it does not work . Tell me where it is manufactured and have a unbiased confirmation what the ingredients are.

Star Scientific employs unethical IR types who's job it is to discredit anyone who says anything bad about them. On the Yahoo Message board for Star Scientific they literally work all day and night to discredit any doubters. They often, every day, try to claim that your blog is fake or a fraud. You really got to wonder why they would do that...right? Star is quit obviously paranoid about people talking about Anatabloc having side effects. Star recently started calling Anatabloc a metabolism product in their SEC filings. Something I'm pretty sure inflammation sufferers do not know about when they buy the product. Additionally, nearly all study results of Anatabloc have been held back from the public. Every one delayed or buried. Lots of alkaloids are terrible for people. I'll leave it at that. Sorry Donna for the insults these people throw your way. Your Dad or his attorney should give execs at Star Scientific an earful as it is their underlings doing the dirt work imho. You should just put these people on ignore. Also John McKeon, who went off on you above, just put $12 mil into Star. That's why he is so angry. He has ties to Star's IR firm Wolfe Axelrod. If you do a search on Google for 'sonic solutions wolfe axelrod john mckeon' you will find sec filings from Sonic Solutions where both parties got paid for investment consulting services. IR guys like I said.

Dear Donna,

The reason many doubt your authenticity is because those that short stocks are often morally degenerate and will tell any lie required to knock down the share price of a company. They will also set up fake web sites and claim to be someone they are not. If you are really who you say you are I wish the best for you and your family. But I certainly would not trust that you are who you say you are as there as too many scammers masquerading as altruistic helpers that are really just trying to get investors to sell their shares. I have more confidence in studies done and verifiable public information like your father is purchasing shares as opposed to someone claiming to be Rick Sharp's daughter. Anyone who trusts that you are who you say you are is a fool.

If you have any questions please don't hesitate to contact me.

First of all I am an investor in Star, but I am also a user - or have been. I do NOT claim that my side effect will be the same for everyone, just putting it out there. I developed several skin conditions after about three or four months of use. Twice I stopped Anatabloc and they went away, so I have stopped taking it. I have not reported it to Star yet, but will. They tend to be rather rude and form-letter-ish when I have written them in the past about price

Apparently, Alzheimer's is a condition caused by a cascade of interacting processes, undoubtedly inflammation plays a critical role, also a breakdown of the blood brain barrier, allowing toxins entry into the brain, the accumulation of amyloid plaques, etc play a role in this process, but my gut feeling is that if inflammation can be damped down, this cascade can be prevented. I believe anatabloc, should be looked at closely for a broad range of conditions for which inflammation appears to be at the very root. I wonder if evidence suggests that Anatabine can pass the blood brain barrier efficiently.

Sorry ... the rest of #2

#2


GLEN ALLEN, Va., Nov. 27, 2012 /PRNewswire/ -- Star Scientific, Inc. (NASDAQ: STSI) today announces that new anatabine research has been accepted by and published online in the European Journal of Pharmacology. In a series of studies, researchers at the Roskamp Institute demonstrated that anatabine can suppress brain inflammation in animal models of Alzheimer's disease, inflammation in the blood in mice, and inflammation induced in human blood once removed from the body. This peer-reviewed data supporting the view that anatabine has widespread anti-inflammatory properties was published in a paper, titled, "Anti-inflammatory Activity of Anatabine Via Inhibition of STAT3 Phosphorylation". The anatabine used in these studies is made under Star Scientific's patented process and is the main ingredient in its Anatabloc® dietary supplement.

In one study, the highly inflammatory molecule LPS, which is released from bacteria during human infections, was injected into mice. Subsequently, there were expected large increases in inflammatory molecules in the blood, spleen, and kidney; however, when co-treated with anatabine there were statistically significant large decreases in these inflammatory molecules in the blood, spleen, and kidney. The spleen, in particular, showed marked suppression of inflammatory molecule release during co-treatment with anatabine.

In addition, the Roskamp Institute team showed that in a mouse model of Alzheimer's disease, supplementation with anatabine resulted in a significant suppression of inflammatory markers, especially a marker called TNF-Alpha, which is known to be raised in Alzheimer's disease. This finding complements a previous study by the Roskamp Institute showing reduction of the amyloid protein in this mouse model of Alzheimer's after treatment with anatabine. The reduction of the accumulation of amyloid and inflammation in the brain are known to be intimately linked, one increasing the other. Therefore, anatabine's reduction of both amyloid levels and inflammation encourage the hypothesis that anatabine may be a useful treatment for Alzheimer's disease.

Finally, the research team showed that a key mediator of inflammation known as STAT3, which is activated during inflammation, was suppressed in the presence of anatabine in spleen, kidney, and brain of mice, and cultured human neurons and human white cells. The entire manuscript can be viewed at: http://dx.doi.org/10.1016/j.ejphar.2012.11.017

Dr. Michael Mullan, the CEO and President of the Roskamp Institute stated, "Anatabine continues to demonstrate widespread anti-inflammatory properties in a broad array of pre-clinical models. Given the commonality of inflammatory systems in rodents and humans, there's much reason to expect that anatabine will demonstrate similar properties in humans. In fact, the team went on to demonstrate that in human blood inflamed with LPS, the presence of anatabine dramatically dampened the inflammatory response, a result also included in the paper."

Paul L. Perito, Star Scientific's Chairman, President and COO, stated, "Our research partner, the Roskamp Institute, has once again secured publication of its cutting edge science in the prestigious European Journal of Pharmacology. This publication underscores the worthy productivity of Dr. Michael Mullan (MD/PhD) and his talented cadre of research scientists, who have better illuminated another contour of anatabine's anti-inflammatory properties. It is one thing to know that our anatabine compound has biological effects; it is far better to have mechanistic data that supports appropriate use and offers a mechanism for those effects."

As previously reported, a human clinical trial analyzing the effects of supplementation with Star Scientific's anatabine compound on individuals with mild to moderate Alzheimer's disease is currently in progress at the Roskamp Institute.